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Mechanism of Gualou Xiebai Banxia Decoction reversal myocardial fibrosis through integrin β1
Author(s): 
Pages: 277-281
Year: Issue:  4
Journal: World Phytomedicines

Abstract: 目的 研究整合素β1和纤维连接蛋白在血管紧张素Ⅱ(AngⅡ)诱导心肌纤维化中的作用,探讨瓜蒌薤白半夏汤(GXB)抗心肌纤维化的作用机制.方法 采用胰酶消化法培养乳鼠心肌成纤维细胞,建立AngⅡ诱导心肌纤维化模型.实验分为空白对照组,Ang Ⅱ组,5%、10%、15%GXB含药血清组和缬沙坦含药血清组.空白对照组心肌成纤维细胞以空白对照组大鼠血清温育,其余各组均以AngⅡ1×10-6mmol/L刺激...
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