Author(s): CAI Jiaqin1, DENG Li2. 1Department of Pharmacology, West China School of Pharmacy, Sichuan University, 610041, P.R.China, 2Division of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University.
Pages: 993-996
Year: 2010 Issue:  8
Journal: Chinese Journal of Reparative and Reconstructive Surgery
Keyword:  Hedgehog信号通路;  MSCs;  成骨分化;  成软骨分化;  成脂分化;
Abstract: 目的综述Hedgehog信号通路对MSCs的增殖和多向分化的调控。方法查阅并综合分析近年有关Hedgehog信号通路对MSCs生物学特性调控的文献,并进行综述。结果 Hedgehog信号通路促进MSCs的增殖,并在其成骨、成软骨分化中发挥重要作用,抑制其成脂分化。结论 Hedgehog信号通路对MSCs增殖与多向分化调控的功能可作为组织或器官缺血、骨质疏松、软骨发育不全和肥胖症等新的治疗靶点。