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Analysis on Antigenicity and Molecular Variation of Newcastle Disease Virus
Author(s): 
Pages: 34-35
Year: Issue:  22
Journal: China Poultry

Abstract:  1 新城疫病毒的变异选择与免疫原性密切相关的新城疫病毒(NDV)HN基因,对不同基因型(F基因型为Ⅰ~Ⅶ)的NDV参考株在HN基因ORF编码区内,进行了同义替代(Ks)和非同义替代(Ka)的比较,重点对11株国内流行的NDV强毒株(F基因型为Ⅶd)与疫苗株(La Sota)在HN基因ORF内进行氨基酸变异比较.结果显示,在自然条件下,Ks值远大于Ka,Ka/Ks<1,显示出NDV以点突变发生为...
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