Author(s): BAO Jie, LUO Xianyang, ZHU Lixiang, WANG Rui, YUAN Liguo
Pages: 25-27
Year: 2010 Issue:  22
Journal: China Poultry
Keyword:  土霉素; 生理房室模型; 鸡; 药动学参数;
Abstract: 为预测土霉素在鸡体内的药动学特点,建立了土霉素在鸡体内的血流限速生理房室模型.结果显示,土霉素在鸡体内的药动学参数:Tmax(达峰时间)为2.22 h,Cmax(峰浓度)为0.62μg/mL,AUC(药时曲线下面积)为7.61(μg/mL)×h,Ka(吸收速率常数)为1.21 h-1,Ke(消除速率常数)为0.10 h-1,T1/2Ka(吸收半衰期)为0.57 h,T1/2Ke(消除半衰期)为6....