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Immunohistochemical studies on vascular endothelial growth factor (VEGF) for the postmortem diagnosis of sudden coronary death
Author(s): 
Pages: 6-7,封三
Year: Issue:  1
Journal: JOURNAL OF FORENSIC MEDICINE

Keyword:  冠心病猝死血管内皮生长因子免疫组织化学;
Abstract: 运用免疫组化SABC法和图像分析与统计学处理系统,对16例冠心病猝死和15例非冠心病猝死对照组尸检心脏标本心肌局部血管内皮生长因子(VEGF)的表达进行了研究.结果:16例冠心病猝死心脏标本心肌梗死局部心肌均有VEGF的阳性表达,尤以心肌梗死灶边缘为甚,阳性表达率为100%.15例非冠心病猝死对照组心脏标本仅有2例心肌局部散在有VEGF弱阳性表达,其余为阴性.将免疫组化染色结果进行图像定量分析与统计学处理,冠心病猝死组阳性指数为13.68±2.73,对照组为2.05±0.84,两组结果有极显著性差异(P<0.01).本研究结果提示,VEGF免疫组化染色可望为冠心病猝死的死后诊断提供一个比较客观的病理形态学依据.
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