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Pharmacodynamic properties and anti-tumor activity of YLS002
Pages: 661-664
Year: Issue:  11
Journal: World Clinical Drugs

Abstract: 目的 评价吡啶类衍生物YLS002在体内及体外抗肿瘤作用.方法 采用四甲基偶氮唑比色法体外检测YLS002对13种肿瘤细胞株的生长抑制作用,建立Colon 26结肠癌荷瘤小鼠模型和A549肺癌荷瘤裸小鼠模型,评价YLS002在体内的抗肿瘤活性.结果 YLS002具有很强的细胞毒作用,体外IG50约为0.22~6.74μg/mL.静脉注射剂量为0.062 5、0.25和1.0 mg/kg的YLS00...
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