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The effects of methomyl on the synaptic transmission of the 6th abdominal ganglion of cockroach
Author(s): 
Pages: 1-6
Year: Issue:  1
Journal: ACTA ENTOMOLOGICA SINICA

Keyword:  灭多威美洲大蠊突触传递;
Abstract: 用电生理学方法研究了灭多威对美洲大蠊Periplaneta americana腹六神经节(A6节)突触传递的影响.用灭多威溶液浸泡A6节,电刺激尾须神经粗支,用甘露醇间隙法记录兴奋性突触后电位(EPSP)和突触后动作电位.给予弱刺激只记录到EPSP时,灭多威作用初期EPSP幅度增加、时程延长,能诱发突触后动作电位,随后EPSP逐渐减小至消失,冲洗可恢复,突触前反应保持不变.增加电刺激强度记录到突触后动作电位时,灭多威可阻断A6 节的突触传递,阻断时间是浓度依赖性的,阻断是可逆的,但冲洗30 min仍保留一定的后作用.对美洲大蠊雄性成虫腹腔注射灭多威测定致死中量(LD50)为(3.56±0.01)μg/g体重.根据灭多威的作用机理对其阻断A6节突触传递的特点以及对虫体的毒杀机制进行了讨论.
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