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Response of keloid fibroblasts to down-regulation on colla-gen synthesis by interferon alpha-2b
Author(s): 
Pages: 13-15
Year: Issue:  1
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  瘢痕疙瘩成纤维细胞胶原合成干扰素α-2b;
Abstract: 为探讨瘢痕疙瘩成纤维细胞对干扰素α-2b(IFNα-2b)作用的反应性,用IFNα-2b分别处理体外培养正常皮肤与瘢痕疙瘩中的成纤维细胞,采用3H-脯氨酸掺入、胃蛋白酶消化法检测成纤维细胞胶原合成量.结果发现,瘢痕疙瘩成纤维细胞经103U/mL的IFNα-2b作用后的胶原合成量显著降低.
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