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Effects of 5-fluorouracil on insulin secretion and apoptosis of NIT-1 beta cells
Author(s): 
Pages: 1687-1689
Year: Issue:  11
Journal: Chinese Journal of Experimental Surgery

Keyword:  5-fluorouracilβ-cellsInsulinApoptosis;
Abstract: 目的 观察5-氟尿嘧啶(5-Fu)对NIT-1细胞株胰岛素分泌、凋亡、超微结构及增殖的影响,探讨其诱发糖尿病的机制.方法 以不同浓度5-Fu处理小鼠胰岛细胞株NIT-1细胞,分别以放射免疫分析法、AnnexinV/PI双染色流式细胞术检测细胞胰岛素释放量及细胞凋亡率的变化;以透射电镜观察细胞超微结构的变化;以噻唑蓝(MTT)比色法检测细胞增殖.结果 在5-Fu(5.0~40.0 mg/L)作用下,...
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