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Repair of knee joint articular osteochondral defects with collagen complex gradient hydroxyapatite biphasic scaffold loaded with chondrocytes in rabbits
Author(s): 
Pages: 1577-1579,后插1
Year: Issue:  11
Journal: Chinese Journal of Experimental Surgery

Keyword:  CollagenHydroxyapatiteTissue engineeringChondrocyteOsteochondral defect;
Abstract: 目的 探讨胶原复合梯度羟基磷灰石(Col/HA)双相支架负载软骨细胞修复兔膝关节骨软骨缺损的可行性及疗效.方法 构建Col/HA双相支架,将软骨细胞种植于支架培养1周,再将软骨细胞-支架复合体移植修复兔膝关节股骨髁的骨软骨缺损,并对骨软骨缺损的修复进行检测.结果 光镜及扫描电镜观察显示软骨细胞在Col/HA支架中贴附良好,表型维持稳定,分泌胞外基质.大体观察和组织学检测显示,植入体内16周后实验组...
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