Effects of dexamethasone on CTLA-4 expression and apoptosis in lymphocytes obtained from children with mesangial proliferative nephritis
Author(s): WANG Feng-Ying, LU Si-Guang, LUO Rong-Hua
Pages: 957-960
Year: 2009 Issue: 12
Journal: Chinese Journal of Contemporary Pediatrics
Keyword: Mesangial proliferative glomerulonephritis; CTLA-4; Dexamethasone; Apoptosis; Child;
Abstract: 目的 原发性系膜增生性肾炎(MsPGN)的发病机制和糖皮质激素(GcC)耐药机制虽然部分已明确,但其确切机制仍未阐明.细胞毒性T淋巴细胞相关抗原(CTLA-4)是T细胞活化的重要抑制性分子.本研究探讨MsPGN患儿外周血淋巴细胞CTLA-4表达和淋巴细胞凋亡及地塞米松(Dex)对其影响.方法 分别采用直接免疫荧光、流式细胞仪及Annexin V-FITC/PI双染流式细胞仪检测:Dex处理或非De...
Pages: 957-960
Year: 2009 Issue: 12
Journal: Chinese Journal of Contemporary Pediatrics
Keyword: Mesangial proliferative glomerulonephritis; CTLA-4; Dexamethasone; Apoptosis; Child;
Abstract: 目的 原发性系膜增生性肾炎(MsPGN)的发病机制和糖皮质激素(GcC)耐药机制虽然部分已明确,但其确切机制仍未阐明.细胞毒性T淋巴细胞相关抗原(CTLA-4)是T细胞活化的重要抑制性分子.本研究探讨MsPGN患儿外周血淋巴细胞CTLA-4表达和淋巴细胞凋亡及地塞米松(Dex)对其影响.方法 分别采用直接免疫荧光、流式细胞仪及Annexin V-FITC/PI双染流式细胞仪检测:Dex处理或非De...
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