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Construction of sortase protein knock-out mutant of Streptococcus suis and analysis of virulence
Author(s): 
Pages: 17-20,26
Year: Issue:  8
Journal: Heilongjiang Animal Science and Veterinary Medicine

Keyword:  srtA基因敲除;
Abstract: 为了研究对猪链球菌2型致病力的影响,试验构建srtA基因缺失株,体外观察突变株05ZYH33△srtA的基本生物学性状,并以猪为动物模型检测突变株05ZYH33△srtA的毒力.结果表明:成功构建了srtA基因缺失株,突变株生物学性状无明显改变,毒力相对于亲本株有所下降.说明了srtA基因对菌株的生物学性状无明显影响,可能是猪链球菌2型潜在毒力因子.
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