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a tuo fa ta ting dui man xing xin li shuai jie bing ren xin gong neng ji zhong liu huai si yin zi de ying xiang
Author(s): 
Pages: 1158-1159
Year: Issue:  10
Journal: Research of Traditional Chinese Medicine

Keyword:  慢性心力衰竭 阿托伐他汀 肿瘤坏死因子;
Abstract: 目的探讨慢性心力衰竭(CHF)病人肿瘤坏死因子(TNF-α)的变化及阿托伐他汀对其的干预作用。方法将70例CHF病人随机分为阿托伐他汀组和常规治疗组,采用放免法测定CHF病人TNF-α浓度、左室射血分数(LVEF)、左室舒张末内径(LVDd)。结果随着NYHA心功能分级的升高,TNF-α逐渐升高(P<0.05);TNF-α与LVEF呈负相关,与LVDd呈正相关;阿托伐他汀组治疗后TNF-α水平显著降低(P<0.05),LVEF显著提高(P<0.05),LVDd显著降低(P<0.05),与常规治疗组治疗后比较差异也有统计学意义(P<0.05)。结论在常规治疗的基础上加用阿托伐他汀能进一步降低TNF-α水平,改善心功能。
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