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Relationship of Hypoxia-inducible Factor-1α and Invasion of Gastric Cancer Cells in Hypoxia
Author(s): 
Pages: 696-699
Year: Issue:  7
Journal: Chinese Journal of Biologicals

Keyword:  缺氧诱导因子1α亚基胃肿瘤RNA干扰细胞黏附游走肿瘤侵袭;
Abstract: 目的 探讨缺氧状态下及缺氧诱导因子-1α(Hypoxia-inducible factor-1α,HIF-1α)RNA干扰后,HIF-1α的表达及其与胃癌细胞黏附、游走、侵袭能力的相关性.方法 将HIF-1α shRNA真核表达质粒pGPU6/GFP/Neo-HIF-1α-2484转染胃癌细胞SGC-7901,构建靶向干扰HIF-1α表达的SGC-7901稳定转染细胞株;采用Western blo...
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