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Synthesis of Isomer of Clopidogrel
Author(s): 
Pages: 8-10
Year: Issue:  9
Journal: Zhejiang Chemical Industry

Abstract: 以邻氯苯甘氨酸甲酯和2-(3-噻吩乙醇)对甲苯磺酸酯为原料,经过氨基取代、Mannich反应和成盐三步反应合成了氯吡格雷异构体α-(2-氯苯基)-4,5-二氢噻吩并[2,3c]吡啶-6(7H)乙酸甲酯硫酸盐,总收率达56%.本方法具有原料易得、反应条件温和、收率较高的优点.
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