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The relevance between clinical behavior and cell proliferation of acoustic neuroma
Author(s): LUO Qizhong, BIAN Liuguan, SHEN Jiankang, QIU Yongming, WANG Yong
Pages: 32-
34
Year: 2000
Issue:
1
Journal: CHINESE JOURNAL OF NEUROSURGERY
Keyword: 听神经瘤; 肿瘤细胞增殖; 肿瘤生长速率;
Abstract: 目的分析听神经瘤临床特性与Ki-67、PCNA增殖指数之间的相关性.方法回顾性分析43例听神经瘤,计算其生长速率,Ki-67、PCNA免疫组织化学观察肿瘤增殖,Spearman等级相关回归分析年生长率与Ki-67、PCNA增殖指数之间的相关性.结果发现患者病程、肿瘤生长指数与增殖指数之间有显著的相关性,复发肿瘤的增殖指数显著高于非复发肿瘤,囊性肿瘤的增殖指数显著低于非囊性肿瘤,肿瘤直径>3.5cm的增殖指数显著高于≤3.5cm者.结论本研究结果提示肿瘤增殖指数越高,肿瘤生长越快,肿瘤直径>3.5cm的肿瘤更易增殖.
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