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Effect of Leptin on Activity of Proliferation and Phagocytosis in THP-1 Cells and Its Mechanism
Author(s): 
Pages: 1049-1051
Year: Issue:  6
Journal: Practical Preventive Medicine

Abstract: 目的 探讨瘦素对人单核细胞系THP-1增殖和吞噬活性的影响,为阐明瘦素在抗感染免疫中的作用提供依据.方法 采用CCK-8法检测瘦素处理前后THP-1细胞的增殖活性,采用流式细胞术测定瘦素处理前后THP-1细胞对白色念珠菌的吞噬情况,RT-PCR检测甘露糖受体(MR)的表达情况.结果 经瘦素处理后,THP-1细胞出现明显增殖(P<0.01),且呈现明显的剂量-效应关系.瘦素处理后的THP-1细胞对白...
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