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Imbalanced expression of Smad7/Psmad2 in STZ-induced diabetic nephropathy rat kidneys
Pages: 2488-2490
Year: Issue:  14
Journal: The Journal of Practical Medicine

Keyword:  糖尿病肾病Smad7Psmad2CollagenⅣ;
Abstract: 目的:动态观察大鼠糖尿病肾病发生发展过程中转化生长因子(TGF)-β1的下游正负反馈调节因子Smad7、Psmad2在肾脏的表达变化及对细胞外基质主要成分CollagenⅣ表达的影响.方法:40只SD大鼠随机分成4组:CON、DM4W、DM8W、DM16W组.STZ诱导糖尿痛肾病模型,Masson染色动态观察各组大鼠胶原合成变化.Western blot、免疫组化方法动态观察Smad7、Psmad...
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