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Inhibition of oxidative stress and NADPH oxidase expression by bifidobacterium in mice with ulcerative colitis
Pages: 2491-2493
Year: Issue:  14
Journal: The Journal of Practical Medicine

Keyword:  结肠炎溃疡性双歧杆菌氧化应激NADPH氧化酶;
Abstract: 目的:观察溃疡性结肠炎(UC)氧化应激及NADPH氧化酶表达的变化特点,探讨双歧杆菌对UC治疗的可能机制.方法:采用葡聚糖硫酸钠(DSS)制作UC小鼠模型,小鼠随机分成3组:正常对照(NC)组、模型(MD)组、双歧杆菌治疗(BT)组.造模同时给予干预治疗7 d,停用造模药物后续治疗7 d后处死小鼠,结肠组织HE染色:化学比色法测结肠SOD,GPH-Px,MPO和MDA;qRT-PCR测NADPH氧...
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