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Relationship of oxidative DNA damage and expression of mitochondrial apoptotic proteins in rat striatum induced by 6-hydroxydopamine
Author(s): 
Pages: 2074-2077
Year: Issue:  29
Journal: National Medical Journal of China

Keyword:  Parkinson\'s diseaseStriatumMitochondriaApoptosis;
Abstract: 目的 检测帕金森病(PD)模型大鼠纹状体内氧化DNA损伤相关指标及线粒体凋亡通路相关蛋白的表达.方法 将6-羟基多巴胺(6-OHDA)通过立体定位仪注入大鼠右侧纹状体制备PD模型,4周后观察行为学改变,5周后检测正常对照、假手术和模型组大鼠右侧纹状体内8-oxo-2\'-deoxyguanosine(8-oxo-dG)免疫组化染色,Western印迹检测DNA损伤修复蛋白MTH1及线粒体凋亡通路相关...
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