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The establishment of chronic parkinson\'s desease in mouse model induded by mptp
Pages: 1149-1151
Year: Issue:  8
Journal: Journal of Chongqing Medical University

Keyword:  帕金森病1-甲基-4-苯基-1236-四氢吡啶α-突触核蛋白细胞凋亡;
Abstract: 目的:观察慢性长期小剂量注射1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)对小鼠黑质多巴胺能神经元损伤及α-突触核蛋白(α-synuclein蛋白)表达的影响.方法:C57BL小鼠背部皮下注射MPTP 25 mg/kg体重,每周注射2次,连续注射5周,观察小鼠行为学改变,应用免疫组化染色检测酪氨酸羟...
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