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Issue:
Abnormal T cell autoimmunity against GAD65 in LADA patients
Author(s):
ZHANG Yi
,
ZHOU Zhi-guang
,
YANG Lin
,
LIN Jian
,
LI Xia
,
HE Wei-min
Pages:
1963
-
1965
Year:
2010
Issue:
28
Journal:
National Medical Journal of China
Keyword:
Diabetes mellitus
;
type1
;
Immunity
;
cellular
;
T-lymphecytes
;
Enzyme linked immune spot assay
;
Abstract:
目的 探讨成人隐匿性自身免疫糖尿病(LADA)患者细胞水平的免疫发病机制.方法 湖南省1型糖尿病协作中心2005年1至6月就诊的LADA患者17例,2004年3月至2006年1月就诊的2型糖尿病(T2DM)患者28例,健康者(对照)16名;放射配体法检测胰岛自身抗体;连续密度梯度离心法分离人外周血单个核细胞;酶联免疫斑点法检测谷氨酸脱羧酶(GAD65)反应性、Th1、Th2细胞,两者比值示为Th1...
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