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Influence of mutations in epidermal growth factor receptor gene on growth, metastasis and survival rate of non-small cell lung carcinoma
Pages: 1808-1812
Year: Issue:  26
Journal: National Medical Journal of China

Keyword:  Carcinomanon-small-cell lungReceptorepidermal growth factorMutationNeoplasm metastasisSurvival rate;
Abstract: 目的 探讨表皮生长因子受体(EGFR)基因突变对非小细胞肺癌(NSCLC)患者预后的影响.方法 收集厦门大学附属中山医院2005年12月至2009年8月107例NSCLC患者的手术切除癌组织标本,采用PCR扩增和基因测序方法检测EGFR外显子18~21突变,分析基因突变对患者肿瘤生长、转移及生存率的影响.结果 107例患者中检出EGFR基因突变者30例(28.0%),其中外显子18突变1例,外显子...
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