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The relationship between G894T polymorphism of endothelial nitric oxide synthase gene and spontaneous aneurismal subarachnoid hemorrhage
Author(s): 
Pages: 422-425
Year: Issue:  5
Journal: Chinese Journal of Neurosurgery

Keyword:  Endothelial nitric oxide synthase geneGene polymorphismIntracranial aneurysmSubarachnoid hemorrhage;
Abstract: 目的 研究eNOS基因第7外显子G894T多态性与动脉瘤性蛛网膜下腔出血(aSAH)的相关性.方法 利用聚合酶链反应(PCR)、琼脂糖凝胶电泳验证PCR反应产物,限制性片段长度多态性(RFLP)分析比较aSAH患者和对照者eNOS基因型的构成及等位基因频率的分布.结果 aSAH患者组的GT+TT基因型和T等位基因频率显著高于对照组,差异具有统计学意义.基因型分布在破裂的颅内动脉瘤直径大小之间差异无...
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