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Association of Plasma E-selectin,S128R Gene Polymorphisms and Cerebral Infarction in Shanxi Han Population
Author(s): 
Pages: 549-551
Year: Issue:  5
Journal: Research of Traditional Chinese Medicine

Keyword:  E-选择素 脑梗死 基因 多态性;
Abstract: 目的检测脑梗死患者血浆E-选择素水平及基因S128R多态性,探讨其与脑梗死的关系。方法脑梗死组73例,对照组85例,用PCR-RFLP法对DNA多态性进行分析,ELISA法检测血浆E-选择素水平。结果发现3个基因型(SS、SR、RR),其基因型频率和等位基因频率在脑梗死组和对照组比较,差异均有统计学意义(P<0.05),相对风险度分析,R等位基因携带者患脑梗死的风险性是S等位基因的4.958倍;脑梗死患者血浆E-选择素水平高于对照组(t=13.139,P<0.05),且脑梗死合并高血压、高脂血症患者的血浆E-选择素浓度高于无并发症组(P<0.05)。结论E-选择素基因S128R多态性与山西汉族人群脑梗死的发病相关,R等位基因可能是山西汉族人群脑梗死发生的危险因素之一;脑梗死患者血浆E-选择素水平明显升高,且浓度与有无合并高血压和高脂血症密切相关。
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