Author(s): YAO Fangfang1, GUO Changcun2, JING Jie2, HOU Peng1(1departmentofgastroenterology, THE Firstaffiliatedhospitalofchinesepeopleliberationarmygeneralhospital, BEIJING 100037, china, 2 Departmentofgastroenterology, STATE Keylaboratoryoftumorbiology, XIJING Hospital, FOURTH Militarymedicaluniversity, XI An710032, china)
Pages: 1217-1219
Year: 2010 Issue:  7
Journal: Biomagnetism
Keyword:  RUNX3;  SLC22A4;  PPAR-γ;  溃疡性结肠炎;  遗传易感性;  SNP;
Abstract: 目的:探讨RUNX3(rs2236851,A→G)、SLC22A4(rs3792876,C→T)和PPAR-γ(rs3892175,A→G)基因的单核苷酸多态性(Single Nucleotide Polymorphism,SNP)与溃疡性结肠炎(ulcerativecolitis,UC)遗传易感性之间的关系。方法:选取经过临床表现、内镜、病理等方法共同确诊的UC患者81例,健康对照组154例,提取患者的全血基因组DNA,用聚合酶链反应序列特异性引物(PCR-SSP)的方法,检测UC患者、SLC22A4和PPAR-γ的基因型分布,并与健康对照组进行比较。结果:RUNX3的rs2236851位点的多态性与UC紧密相关(P<0.05);而SLC22A4的rs3792876位点与PPAR-γ的rs3892175位点的基因型分布与对照组相比,其差异无统计学意义(P>0.05)。结论:RUNX3的rs2236851位点的基因多态性为溃疡性结肠炎的遗传易感因素,而SLC22A4的rs3792876位点与PPAR-γ的rs3892175位点的基因多态性与溃疡性结肠炎的遗传易感性无关。