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The influence of erythropoietin to the ultrastructure of retinal neurons and content of retinal glutamate in the earIy stmge dialmtic rats
Author(s): ZHU Zuozuo, WANG Weijun, XU Xun
Pages: 246-
249
Year: 2008
Issue:
4
Journal: Ophthalmology in China
Keyword: 糖尿病视网膜病变; 促红细胞生成素; 谷氨酸; 动物模型;
Abstract: 目的 探讨重组人促红细胞生成素(EP0)对于早期糖尿病大鼠视网膜超微结构和谷氨酸的影响.设计实验性研究.研究对象早期糖尿病大鼠.方法 1%链脲佐菌素(STZ)腹腔内注射建立糖尿病大鼠模型,成模2周后腹腔注射EPO进行干预,每周3次,共2周.大鼠视网膜组织切片透射电子显微镜观察.用柱前衍生高效液相色谱法测定大鼠视网膜内谷氨酸水平.主要指标大鼠视网膜谷氨酸含量和超微结构改变.结果 4周末,STZ诱导糖...
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