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Preparation of galantamine hydrobromide patch and its release and transdermal properties in vitro
Pages: 135-137
Year: Issue:  2
Journal: Pharmaceutical Care and Research

Keyword:  氢溴酸加兰他敏贴剂释放度透皮体外研究阿尔茨海默病;
Abstract: 目的:制备氢溴酸加兰他敏贴剂,并对其体外释放度和体外透皮特性进行考察.方法:采用丙烯酸酯乳液型压敏胶为基质制备氢溴酸加兰他敏贴剂,按<中华人民共和国药典>规定方法进行贴剂的体外释放度测定;采用改良Franz扩散池,以离体小鼠皮肤为屏障进行氢溴酸加兰他敏贴剂的体外透皮特性研究.结果:氢溴酸加兰他敏贴剂的体外释放符合Higuchi方程,24 h累积释药量占总药量的41.81%;体外透皮符合零级方程,2...
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