Mechanisms of decorin inhibiting epithelial-to-mesenchymal transition induced by transforming growth factor β1 in renal tubular epithelial cells
Author(s): WANG Jin-ya, BAO Hua-ying, HUANG Song-ming, ZHANG Ai-hua, PAN Xiao-qin, FEI Li, CHEN Rong-hua
Pages: 50-54
Year: 2010 Issue: 1
Journal: Chinese Journal of Pediatrics
Keyword: Proteoglyeans; Inhibitor of differentiation protein; Fibrosis; Nephrology; Transforming growth factor betal;
Abstract: 目的 研究核心蛋白聚糖抑制转化生长因子β1(TGF-β1)诱导的人肾小管上皮细胞-间充质细胞-转分化(EMT)的机制.方法 将体外培养的人肾小管上皮细胞(HK-2)分为4组:(1)阴性对照组;(2)100 ng/ml核心蛋白聚糖组;(3)10 ng/ml TGF-β1组;(4)100 ng/ml核心蛋白聚糖和10ng/ml TGF-β1组.Western blot法检测信号通路ERK、PI3K、S...
Pages: 50-54
Year: 2010 Issue: 1
Journal: Chinese Journal of Pediatrics
Keyword: Proteoglyeans; Inhibitor of differentiation protein; Fibrosis; Nephrology; Transforming growth factor betal;
Abstract: 目的 研究核心蛋白聚糖抑制转化生长因子β1(TGF-β1)诱导的人肾小管上皮细胞-间充质细胞-转分化(EMT)的机制.方法 将体外培养的人肾小管上皮细胞(HK-2)分为4组:(1)阴性对照组;(2)100 ng/ml核心蛋白聚糖组;(3)10 ng/ml TGF-β1组;(4)100 ng/ml核心蛋白聚糖和10ng/ml TGF-β1组.Western blot法检测信号通路ERK、PI3K、S...
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