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Effect of oxyhemoglobin on the DNA - binding activity of nuclear factor-κB in cultured vascular smooth muscle cells
Author(s): 
Pages: 116-119
Year: Issue:  2
Journal: Chinese Journal of Neurosurgery

Keyword:  Cerebral vasopasmSubarachnoid hemorrhageOxyhemoglobinVascular smooth muscle cellsNF -κB;
Abstract: 目的 观察氧合血红蛋白(OxyHb)对培养的血管平滑肌细胞(VSMCs)细胞密度及核因子(NF)-κB的DNA结合活性的影响.方法 用不同浓度(1~100 μmol/L)的OxyHb处理VSMCs,观察其形态学及细胞密度变化,测定NF-κB的DNA结合活性.结果 OxyHb刺激后VSMCs都表现出形态学的改变,其严重程度有浓度依赖性.但是在24 h时只有100 μmol/L组有明显的细胞数量减少,...
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