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The change of apoptosis in the lung injury caused by mechanical ventilation combining hyperoxia in the new-born rabbits
Author(s): HUA Shaodong, DU Jiang, DONG Jianying, SHI Xiaodong, LIU Xiuxiang, FENG Zhichun
Pages: 157-
159,插页2-1
Year: 2009
Issue:
2
Journal: Chinese Pediatric Emergency Medicine
Keyword: Peak inspiratory pressure; Mechanical ventilafton; Acute lung injury; Apoptosis;
Abstract: 目的 研究高浓度氧气吸入并不同的吸气峰压机械通气对新生兔支气管和肺组织细胞凋亡的影响,探讨细胞凋亡在机械通气所致肺损伤中的作用机制及其意义.方法 将60只日龄1~5 d的新生免随机分为高吸气峰压机械通气组(高压通气组)、中压通气组、低压通气组及对照组(未机械通气),通气后1、3、6 h三个时间点处死动物,收集肺组织,采用电镜观察肺组织的超微结构改变,用脱氧核糖核苷酸末端转移酶介导的末端标记法检测损...
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