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EFFECT OF ACTH ON THE EXPRESSION OF SOMATOSTATIN AND c-fos IN THE SPINAL CORD AND FORMALIN EVOKED PAIN RESPONSE
Author(s): 
Pages: 60-64
Year: Issue:  1
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  ACTH生长抑素原癌基因c-fos脊髓免疫组化原位杂交;
Abstract: 本研究应用免疫组化、原位杂交和痛级均数测定法,探讨鞘内注射促肾上腺皮质激素(ACTH)对甲醛引起大鼠脊髓内生长抑素(Som)、c-fos表达及痛反应的影响.结果表明,足底注射甲醛可使大鼠脊髓内c-fos样免疫反应(FLI)、Som样免疫反应(Som-LI)、FLI/Som-LI及前Som原mRNA (PPS-mRNA)神经元数目显著增多以及痛级均数(PIR)显著升高.而鞘内注射ACTH可显著抑制甲醛引起的大鼠脊髓内FLI、Som-LI、FLI/Som-LI及PPS-mRNA增多和PIR升高效应.鞘内预先注射赛庚啶可阻断ACTH的抑制效应,而荷包牡丹碱、纳洛酮则无影响.结果提示,5-羟色胺受体可能参与ACTH抑制甲醛引起的痛反应.
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