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INDUCING ANTIBODY RESPONSE AGAINST E2 GLYCOPROTEIN OF HEPATITIS C VIRUS IN BALB/c MICE BY PLASMID DNA-BASED IMMUNIZATION
Author(s): 
Pages: 395-396
Year: Issue:  5
Journal: JOURNAL OF BEIJING MEDICAL UNIVERSITY

Keyword:  肝炎病毒丙型/免疫学病毒包膜蛋白质类/生物合成抗体生成;
Abstract: 目的:通过基因免疫诱导BALB/c小鼠产生抗Ⅲ型中国株HCV来源E2糖蛋白的体液免疫应答.方法:质粒p3W14在NIH 3T3细胞中能够表达E2糖蛋白,纯化该质粒并用于BALB/c小鼠直接肌注,于加强注射后不同时相采血,以重组的E2糖蛋白检测特异性抗E2抗体.结果:接种p3W14质粒的小鼠中可检出抗E2抗体(5/6),抗体滴度1∶15~1∶120.结论:采用含E2/NS1基因的质粒DNA免疫,成功地诱导小鼠产生抗Ⅲ型株来源的E2抗体.
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