The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
INHIBITORY EFFECT OF ARG-GLY-ASP-SER PEPTIDE ON PHOSPHORYLATION OF GLYCOPROTEIN Ⅱb/Ⅲa IN ACTIVATED RAT PLATELETS
Author(s): 
Pages: 410-412
Year: Issue:  5
Journal: JOURNAL OF BEIJING MEDICAL UNIVERSITY

Keyword:  RGDS肽氧化磷酸化/拮抗剂和抑制剂血小板膜糖蛋白类/代谢;
Abstract: 目的:研究Arg-Gly-Asp-Ser(RGDS)肽对血小板聚集和血小板膜GP Ⅱb/Ⅲa反磷酸化的影响.方法:免疫沉淀提取血小板膜GP Ⅱb/Ⅲa,反磷酸化测定.结果:50 μmol*L-1 ADP引起血小板聚集时,其GP Ⅱb/Ⅲa反磷酸化明显降低.而应用100和200 μmol*L-1 RGDS肽与ADP共同孵育,呈浓度依赖抑制血小板聚集的同时,可逆转ADP引起的蛋白反磷酸化改变(P<0.01),其抑制血小板聚集和GP Ⅱb/Ⅲa反磷酸化呈明显的负相关(r=-0.76,P<0.01).结论:RGDS肽抑制血小板聚集是通过抑制血小板膜GP Ⅱb/Ⅲa磷酸化所致.
Related Articles
No related articles found