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L-PHENYLALANINE AND SMOOTH MUSCLE CELL PROLIFERATION FROM SHR AND WKY RATS
Author(s): 
Pages: 401-408
Year: Issue:  4
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  L-phenylalaninevascular smooth muscle cellscell growth;
Abstract: Cell growth and proliferation were evaluated in cultured vascular smooth muscle cells (VSMCs) isolated from spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto (WKY) rat aortae by measuring [3H]-thymidine incorporation into newly synthesized DNA and by determining cell number, respectively. The results showed that in cultures from both rat strains ( 1 ) serum-, basic fibroblast growth factor (bFGF)- and thrombin-induced DNA synthesis were inhibited by L-phenylalanine dosedependently; (2) L-phenylalanine inhibited cell proliferation in response to serum in a concentrationdependent manner; (3) L-phenylalanine inhibited serum-induced proto-oncogene c-fos and c-myc expression;(4) L-tyrosine, L-histidine and D-phenylalanine failed to mimic the inhibitory effect of L-phenylalanine. All these data demonstrate that L-phenylalanine could exert a direct and specific antiproliferative effect on VSMCs suggesting that such effect can account for the antihypertensive action of this amino acid observed in SHR.
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