The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
REGULATION OF ACTH4-9 ANALOGUE ON THE Ca2+ LEVEL OF MOUSE HIPPOCAMPAL SYNAPTOSOMES
Author(s): 
Pages: 449-452
Year: Issue:  4
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  Org2766海马突触体Fura-2[Ca2+]i45Ca2+摄取;
Abstract: 本工作观察了Org2766(ACTH4-9的类似物)对海马突触体内游离Ca2+水平及对45Ca2+摄取的影响.采用细胞内钙离子荧光探针Fura-2,通过Spex-阳离子测定系统检测突触体内[Ca2+]i的动态变化,并用液闪光谱仪测定突触体对45Ca2+的摄取.结果表明:较低剂量的Org2766对突触体内[Ca2+]i的影响不明显,却显著降低突触体对45Ca2+的摄取;高剂量的Org2766增加突触体内[Ca2+]i,但对突触体的45Ca2+摄取无影响.较低剂量的Org2766可拮抗茴香霉素(ANI)升高突触体内[Ca2+]i和45Ca2+摄取量的作用,高剂量的Org2766无此效应.此结果提示,Org2766可通过抑制胞外钙内流和增加胞内钙库的释放来调节胞内钙水平.
Related Articles
No related articles found