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EFFECTS OF TAURINE ENHANCEMENT OF SYNTHESIS OF TxA2 AND PGI2 IN CULTURED INTRA-PULMONARY ARTERIOLAR SMOOTH MUSCLE CELLSUNDER ACUTE HYPOXIA
Author(s): 
Pages: 465-468
Year: Issue:  4
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  血栓素A2前列环素牛磺酸肺小动脉平滑肌细胞吲哚美辛低氧;
Abstract: 本工作观察了牛磺酸(taurine)对分离培养家兔肺小动脉平滑肌细胞(PASMCs)在急性低氧条件下培养液中血栓素B2(TxB2)和6-酮-前列腺素F1α(6-keto-PGF1α)含量及其比值变化的影响,同时用环加氧酶抑制剂吲哚美辛干预,以探讨牛磺酸的作用途径.结果是:低氧使PASMCs培养液中TxB2和6-keto-PGF1α含量及其比值显著增加.常氧和低氧条件下,终浓度为2.5×10-5mol/L的牛磺酸显著降低TxB2的含量,显著提高6-keto-PGF1α的含量,终浓度为2.5×10-3 mol/L的吲哚美辛显著降低TxB2和6-keto-PGF1α含量,牛磺酸和吲哚美辛共同作用,TxB2的含量进一步降低,6-keto-PGF1α含量比单纯用吲哚美辛增加明显.这些结果表明,牛磺酸可能通过抑制PASMCs内的TxA2合成酶的活性和增强前列环素(PGI2)合成酶的活性拮抗低氧增强PASMCs产生TxA2和PGI2,使TxA2与PGI2的比值显著降低而逆转低氧性肺血管收缩.
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