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Magnetic resonance spectroscopy of the thalamus in essential tremor patients
Author(s): WU Peijun, WANG Qi, LI Wei, ZHAO Wenrong, PENG Yifeng, TANG Guangyu(departmentofradiology, NO.10 Peopleshospitalaffiliatedtoshanghaitongjiuniversity, SHANGHAI 200072, china)
Pages: 133-
137
Year: 2010
Issue:
2
Journal: Railway Medical Journal
Keyword: 神经元退行性疾病; 特发性震颤; 丘脑; 磁共振波谱;
Abstract: 目的:应用氢质子磁共振波谱(1H-MRS)成像方法研究特发性震颤(ET)患者双侧丘脑的代谢物变化情况。方法:对14名ET患者和8名健康成人(为对照组)的双侧丘脑进行1H-MRS检查,计算N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)的比值,并对患者采用Fahn-Tolosa-Marin震颤评定量表进行评分。结果:ET患者症状较明显肢体的相关侧丘脑较非相关侧丘脑的NAA/Cr值升高(1.63±0.25vs1.56±0.26),ET患者双侧丘脑感兴趣区内NAA/Cr值较对照组双侧丘脑NAA/Cr均值升高(1.63±0.25vs1.49±0.35),但差异均无统计学意义(P>0.05)。结论:ET患者双侧丘脑并未发现神经元损伤丢失现象,其在该病发生发展中起到的作用还有待进一步研究。
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