Author(s): LIU Longbin, GUO Hangyuan, SHI Yafei, SUN Aijing, XU Fukang, CHI Jufang, XING Yangbo
Pages: 676-680
Year: 2010 Issue:  4
Journal: Chinese Journal of Pathophysiology
Keyword:  Yellow wine; Matrix metalloproteinase-2; LDL receptor knockout mice; Homocysteine; Atherosclerosis;
Abstract: 目的:观察黄酒是否能减轻动脉粥样硬化斑块的形成并探讨其可能机制.方法:48只6周龄LDLR~(-/-)小鼠,以高脂+高蛋氨酸(标准饲料+10%油脂+1.25%胆固醇+1%L-蛋氨酸)喂养诱导形成高同型半胱氨酸血症并致动脉粥样硬化模型,随机分为:黄酒组、红葡萄酒组、酒精组和对照组,每组12只.14周后处死小鼠,检测血脂及血浆同型半胱氨酸;观察胸腹主动脉和主动脉窦部粥样硬化情况;免疫组化测定主动脉窦部...