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STUDY ON APOPTOSIS IN BLADDER CANCER CELLS INDUCED BY MYTOMYCIN C
Author(s): 
Pages: 202-203
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  膀胱肿瘤 细胞凋亡 丝裂霉素;
Abstract: 为进一步探讨丝裂霉素膀胱内灌注治疗膀胱肿瘤的机制,研究了丝裂霉素诱导人膀胱癌 B I U87 细胞凋亡的规律。形态学观察具有典型凋亡征象,胞浆浓缩,染色质凝集,核固缩、裂解及凋亡小体。凋亡指数与诱导时间呈正相关( P< 0.01);流式细胞仪 D N A 直方图上出现特征性的亚二倍体(亚 G1 )峰;凋亡过程中伴 Bcl2 基因的下调,且与诱导时间呈负相关 ( P< 001)。提示丝裂霉素诱导癌细胞凋亡是腔内化疗的重要机制,降低 Bcl2 的表达可提高膀胱癌腔内化疗的疗效。
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