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EXPRESSION AND CLINICAL SIGNIFICANCE OF HLA CLASS Ⅰ ANTIGENS AND CD54 IN OVARIAN EPITHELIAL CANCER
Author(s): 
Pages: 236-238
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  卵巢肿瘤 HLA抗原 抗原 CD 细胞粘着分子;
Abstract: 用免疫组化 S A B C 法检测 H L A Ⅰ类抗原和 C D 54的表达。结果表明,卵巢上皮癌44 份标本中, H L A Ⅰ类抗原和 C D 54的表达率分别为 5909% 和4551% 。Ⅲ~Ⅳ期的 H L A Ⅰ类抗原阳性表达率显著低于Ⅰ~Ⅱ期;有淋巴结转移者显著低于无淋巴结转移者;肿瘤复发者显著低于未复发者。 C D 54表达则与临床分期、组织分化、淋巴结转移、组织学类型及肿瘤复发无明显相关性,但无 H L A Ⅰ类抗原表达而 C D54表达的患者复发率显著升高。提示卵巢上皮癌可能通过降调 H L A Ⅰ类抗原表达及改变 C D 54的表达等机制逃避机体的免疫监视,检测 H L A Ⅰ类抗原和 C D 54的表达可能有有助于判断卵巢癌患者的预后。
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