VOLTAGE DEPENDENCE OF LATE Na CHANNEL WITH BURST MODE IN ISOLATED CARDIAC MYOCYTES
Author(s): LIU Yuan-Mou, WANG HONG-WEI, LI Ci-Zhen
Pages: 483-490
Year: 1997 Issue: 5
Journal: ACTA PHYSIOLOGICA SINICA
Keyword: 游离心室肌细胞; 膜片箝; 晚钠电流; 模式; 爆发型;
Abstract: 应用膜片箝技术记录豚鼠游离心室肌细胞钠通道电流,发现除极可引起晚钠电流爆发型开放,而复极可终止爆发型活动.爆发型模式的通道电流不仅有浓度依赖性和电位依赖性,其开放时间常数也随箝制电位变正而增大.多步阶梯式除极和斜线除极的实验结果首次表明电位变化愈迅速、除极步数愈多,爆发型出现的机率也就愈高.
Pages: 483-490
Year: 1997 Issue: 5
Journal: ACTA PHYSIOLOGICA SINICA
Keyword: 游离心室肌细胞; 膜片箝; 晚钠电流; 模式; 爆发型;
Abstract: 应用膜片箝技术记录豚鼠游离心室肌细胞钠通道电流,发现除极可引起晚钠电流爆发型开放,而复极可终止爆发型活动.爆发型模式的通道电流不仅有浓度依赖性和电位依赖性,其开放时间常数也随箝制电位变正而增大.多步阶梯式除极和斜线除极的实验结果首次表明电位变化愈迅速、除极步数愈多,爆发型出现的机率也就愈高.
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