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VOLTAGE DEPENDENCE OF LATE Na CHANNEL WITH BURST MODE IN ISOLATED CARDIAC MYOCYTES
Author(s): 
Pages: 483-490
Year: Issue:  5
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  游离心室肌细胞膜片箝晚钠电流模式爆发型;
Abstract: 应用膜片箝技术记录豚鼠游离心室肌细胞钠通道电流,发现除极可引起晚钠电流爆发型开放,而复极可终止爆发型活动.爆发型模式的通道电流不仅有浓度依赖性和电位依赖性,其开放时间常数也随箝制电位变正而增大.多步阶梯式除极和斜线除极的实验结果首次表明电位变化愈迅速、除极步数愈多,爆发型出现的机率也就愈高.
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