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EFFECT OF VASOPRESSIN IN THE ROSTRAL VENTROLATERAL MEDULLA ON PRESSOR RESPONSE INDUCED BY dPAG STIMULATION
Author(s): 
Pages: 491-496
Year: Issue:  5
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  血管加压素头端延髓腹外侧区(rVLM区)防御性升压反应;
Abstract: 雄性Sprague-Dawley大鼠,用乌拉坦(700 mg/kg)和氯醛糖(30 mg/kg)腹腔麻醉.在双侧头端延髓腹外侧区(rVLM区)每侧微量注射血管加压素(AVP)(10 pmol/0.1μl)可引起平均动脉压(MBP)升高,心率(HR)变化不明显,每侧微量注射AVP的V1受体拮抗剂d(CH2)5[Tyr(Me)2]AVP(0.1 nmol/0.1 μl)后MBP和HR无明显变化.若预先在rVLM区每侧微量注射AVP的V1受体拮抗剂(0.1 nmol/0.1μl)后,再在rVLM区同一部位每侧注入AVP(10 pmol/0.1μl),MBP升高作用消失.电刺激中脑(dPAG区)可诱发防御性升压反应.若在双侧rVLM区每侧微量注射AVP的V1受体拮抗剂(0.1 nmol/0.1μl)可对防御性升压反应起部分抑制作用.结果表明,rVLM区内微量注射AVP可引起MBP升高,刺激中脑dPAG区诱发的升压反应均与rVLM区AVP的V1受体的激活有关.
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