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EFFECTS OF INTRAVENTRICULAR AND EPICARDIAL APPLICATION OF ADENOSINE ON ELECTRICAL ACTIVITY OF MEDULLARY PGL NEURONS
Author(s): 
Pages: 504-512
Year: Issue:  5
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  腺苷腺苷受体心交感传入纤维延髓腹外侧头端区;
Abstract: 在35只切断两侧缓冲神经和迷走神经的麻醉大鼠,观察心室内注射腺苷和心外膜涂布腺苷对延髓腹外侧头端区PGL神经元自发电活动的影响.结果如下:(1)35只大鼠共记录到121个自发放电单位,平均放电频率为22.5±1.9 spikes/s.(2)心室内冲击注射腺苷(0.5μmol/kg,0.1ml)时,BP先升(△1.7±0.2 kPa,P<0.001)后降(△4.6±0.5 kPa,P<0.001),HR减慢(△126.5±12.3 bpm,P<0.001);35个PGL神经元自发放电单位中,30个单位的放电频率由21.9±2.6增至29.2±3.4 spikes/s(P<0.001),3个单位不变,2个单位减少.(3)心外膜涂布腺苷(20 mmol/L),动脉血压和心率的变化不明显,22个PGL神经元自发放电频率由18.8±1.9增至26.9±2.8 spikes/s(P<0.001),3个单位的放电频率无变化.(4)静脉注射选择性腺苷A1受体拮抗剂8-eyelopentyl-1,3-dipropylxanthine(DPCPX,500 μg/kg)可完全阻断腺苷对PGL神经元的兴奋效应.(5)在左右房室沟涂布85%酚或切除双侧星状神经节后,腺苷激活PGL神经元的效应即行消失.结果提示,腺苷可通过A1受体激活心交感神经传入纤维,进而兴奋PGL神经元.
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