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INHIBITION OF GASTRIC MOTILITY BY MICROINJECTION OF CCK-8 INTO RAT AMYGDALA
Author(s): 
Pages: 569-574
Year: Issue:  5
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  八肽胆囊收缩素杏仁基底内侧核下丘脑腹内侧核胃内压胃运动;
Abstract: 应用脑核团内微量注射和核团电刺激方法,观察杏仁基底内侧核(BMA)对胃运动的影响,分析BMA与下丘脑腹内侧核(VMH)的机能联系.结果如下:(1)双侧BMA内注射八肽胆囊收缩素(CCK-8)(50ng/1 μl),出现胃内压(IGP)和胃运动频率(GMF)显著下降(P<0.01).(2)BMA内注射CCK-A受体阻断剂[L364,718](100ng/1μl)或CCK-B受体阻断剂[L365,260](100ng/1 μl),IGP和GMF无明显影响.(3)先给予[L364,718](100ng/1μl),再给予CCK-8,IGP和GMF的抑制不再出现;而先给[L365,260],则CCK-8对IGP和GMF的抑制仍出现.(4)在BMA附近如终纹床核杏仁内侧部(BSTIA)和内侧杏仁核(Me)注射CCK-8均未出现IGP和GMP的抑制作用.(5)分别电刺激单侧BMA和VMH,均显著降低IGP和GMF.(6)电损毁单侧VMH后,电刺激同侧BMA或BMA内微量注射CCK-8均不能降低IGP和GMF.这些结果揭示:BMA内CCK-8对IGP和GMF有抑制作用,这种抑制作用是通过BMA内的CCK-A受体激活而实现,CCK-B受体可能不参与.在BMA抑制胃运动的传出通路中,VMH是必须的中介环节.
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