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A STUDY OF THE MECHANISM OF L-NNA ON SLEEP INHIBITION
Author(s): 
Pages: 585-588
Year: Issue:  5
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  睡眠-觉醒周期一氧化氮中缝核5-羟色胺;
Abstract: 本文观察了硝基左旋精氨酸(L-NNA,50 mg/kg,ip)和L-精氨酸(L-arg,110 mg/kg,ip)对慢性植入电极的大鼠睡眠-觉醒周期的影响及中缝核5-羟色胺(5-HT)神经元免疫阳性反应的变化.结果表明:L-NNA显著抑制慢波睡眠和快眼动睡眠,使平均动脉压(MAP)升高.L-arg则使MAP显著降低,对睡眠无明显影响.预先给予L-arg可逆转L-NNA的效应.腹腔给予L-NNA后2 h,中缝背核(DR)和中央上核(MnR)5-HT神经元免疫阳性细胞明显增多,与对照比较,P<O.O1,此效应可被预先给予L-arg所减弱.提示L-arg:NO通路参与睡-醒周期节律的调节.中缝核头部5-HT神经元免疫阳性反应增强可能与L-NNA抑眠作用有关.
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