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INCREASE IN THE LEVEL OF AUGMENTER OF LIVER REGENERATION mRNA IN THE RAT REGENERATING LIVER AFTER PARTIAL HEPATECTOMY
Author(s): 
Pages: 599-601
Year: Issue:  5
Journal: ACTA PHYSIOLOGICA SINICA

Keyword:  肝再生增强因子mRNA肝再生肝部分切除;
Abstract: 肝再生增强因子(ALR)是一种新的肝增殖刺激因子.本研究选择70%肝部分切除(PH)大鼠为模型,观察了PH后残存肝组织胞浆液促肝细胞增殖活性与ALR特异mRNA表达动态变化的关系.发现正常肝组织几无ALRmRNA表达,其肝胞质液也无促肝细胞增殖活性;70%PH后12 h肝组织ALRmRNA表达明显增加,并于术后24 h达高峰,肝胞质液活性也于术后24 h内达高峰,这种mRNA表达-效应的时间关系提示:ALR可能是一种重要的生理性肝再生调控因子.
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