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RELATIONSHIP BETWEEN VEGF EXPRESSION AND ANGIOGENESIS IN LYMPHNODE POSITIVE AND NEGATIVE STATUS OF BREAST CARCINOMA
Author(s): 
Pages: 189-191
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  乳腺肿瘤 内皮生长因子 新生血管化 微血管密度 肿瘤转移 淋巴结;
Abstract: 对 35 例乳癌石蜡切片分别用抗血管内皮生长因子( V E G F)和抗八因子相关抗原(Ⅷ F R Ag)单抗进行免疫组化染色,以探讨 V E G F 的表达水平、微血管密度( M V D)及腋窝淋巴结转移之间的关系。结果显示,腋窝淋巴结有转移者 V E G F 阳性率和 M V D 分别为 7778% 和 9382±2176,无转移者为1768% 和 4350±1103,二者呈正相关。 V E G F 表达和 M V D 不仅可作为乳癌预后指标,而且通过抑制 V E G F 表达和抗血管生成治疗可防止肿瘤复发和转移。对选择其他疗法亦有参考价值。
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