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ANALYSIS OF EFFECT RELATED FACTORS IN PATIENTS WITH APLASTIC ANEMIA TREATED WITH ANTI T LYMPHOCYTE MONOCLONAL ANTIBODIES
Author(s): 
Pages: 220-222
Year: Issue:  3
Journal: Acta Academiae Medicinae Shandong

Keyword:  贫血 再生障碍性 抗体 单克隆 治疗学;
Abstract: 再障 97 例( S A AⅠ 21 例, S A AⅡ 34 例, C A A 42 例)经抗 T 单抗治疗后有效 66 例(6804% )。治疗前 C D+4 / C D+8 比值异常者疗效优于本身正常者,治疗后 T 细胞亚群好转者疗效优于未好转者,治疗后 H L A D R 抗原表达降低者疗效相对高于未降低者,重症型疗效低于慢性型;治疗前病程越长疗效越差;重复治疗不仅安全而且有效,但疗效与初次治疗反应有关,初治无效者重复治疗效果也差;单抗治疗后多在 6 个月内起效,随随访时间的延长疗效略有下降,病毒所致再障疗效相对较差,性别和年龄与疗效无关,3 种治疗方案之间疗效差异无显著性。本结果为合理选用抗 T 单抗治疗提供了依据。
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