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Metabolic Transformation of Cryptotanshinone in Pig Liver Microsomes P_(450)
Pages: 10-13
Year: Issue:  11
Journal: Chinese Journal of Veterinary Science and Technolo

Keyword:  隐丹参酮 猪肝微粒体P_(450) 药物代谢;
Abstract: 用钙离子沉淀法制备猪肝细胞微粒体P450 进行了体外代谢隐丹参酮的研究。用Lowry 法测定肝微粒体蛋白含量平均为2 .460 ±0 .699 mg/ m L;Om ura 法测定猪肝微粒体P450 含量平均为0 .176 ±0 .053 n mol/ m g 。从P450加还原型辅酶Ⅱ的体外代谢系统中分离纯化了2 个主要代谢产物,经光谱分析鉴定为丹参酮ⅡA 与1羟基丹参酮ⅡA,并比较了隐丹参酮在猪体内外的代谢差异。
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